Mitochondrial mutations and metabolic adaptation in pancreatic cancer

BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy for cancers such as pancreatic cancer, which are driven by genetic altera...

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Pubblicato in:Cancer Metab
Autori principali: Hardie, Rae-Anne, van Dam, Ellen, Cowley, Mark, Han, Ting-Li, Balaban, Seher, Pajic, Marina, Pinese, Mark, Iconomou, Mary, Shearer, Robert F., McKenna, Jessie, Miller, David, Waddell, Nicola, Pearson, John V., Grimmond, Sean M., Sazanov, Leonid, Biankin, Andrew V., Villas-Boas, Silas, Hoy, Andrew J., Turner, Nigel, Saunders, Darren N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282905/
https://ncbi.nlm.nih.gov/pubmed/28163917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0164-1
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