APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

BACKGROUND: APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy. METHODS: APP(SW)/PS1(dE9) (APP) transgenic mice with targeted replacement...

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Publicat a:Mol Neurodegener
Autors principals: Pankiewicz, Joanna E, Baquero-Buitrago, Jairo, Sanchez, Sandrine, Lopez-Contreras, Jennifer, Kim, Jungsu, Sullivan, Patrick M., Holtzman, David M., Sadowski, Martin J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282859/
https://ncbi.nlm.nih.gov/pubmed/28143566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0156-1
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