Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid

BACKGROUND: The mammalian target of rapamycin (mTOR) is a kinase involved in a variety of physiological and pathological functions. However, the exact role of mTOR in excitotoxicity is poorly understood. Here, we investigated the effects of mTOR inhibition with rapamycin against neurodegeneration, a...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Saliba, Soraya Wilke, Vieira, Erica Leandro Marciano, Santos, Rebeca Priscila de Melo, Candelario-Jalil, Eduardo, Fiebich, Bernd L., Vieira, Luciene Bruno, Teixeira, Antonio Lucio, de Oliveira, Antonio Carlos Pinheiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282622/
https://ncbi.nlm.nih.gov/pubmed/28143498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0793-x
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