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Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.

Diabetes-prone BB rats spontaneously develop type 1 diabetes due to a T-cell-dependent destruction of insulin-producing beta-islet cells. A number of T-cell abnormalities including lymphopenia, poor cell-mediated responsiveness to alloantigen, and an absence of an RT6+ T-cell subset are associated w...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gold, D P, Bellgrau, D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52826/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658791/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.21.9888
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