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Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.

Diabetes-prone BB rats spontaneously develop type 1 diabetes due to a T-cell-dependent destruction of insulin-producing beta-islet cells. A number of T-cell abnormalities including lymphopenia, poor cell-mediated responsiveness to alloantigen, and an absence of an RT6+ T-cell subset are associated w...

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Detalhes bibliográficos
Main Authors: Gold, D P, Bellgrau, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC52826/
https://ncbi.nlm.nih.gov/pubmed/1658791
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