Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat.
Diabetes-prone BB rats spontaneously develop type 1 diabetes due to a T-cell-dependent destruction of insulin-producing beta-islet cells. A number of T-cell abnormalities including lymphopenia, poor cell-mediated responsiveness to alloantigen, and an absence of an RT6+ T-cell subset are associated w...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52826/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658791/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.21.9888 |
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