HMGB1 Mediates Autophagy Dysfunction via Perturbing Beclin1-Vps34 Complex in Dopaminergic Cell Model

Parkinson’s disease (PD), a progressive neurodegenerative disorder, is characterized by irreversible dopaminergic neuron loss and intra-neuronal α-synuclein aggregation. High mobility group box 1 (HMGB1) has been proven to be involved in autophagy dysfunction induced by α-synuclein accumulation, and...

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Udgivet i:Front Mol Neurosci
Main Authors: Huang, Jinsha, Yang, Jiaolong, Shen, Yan, Jiang, Haiyang, Han, Chao, Zhang, Guoxin, Liu, Ling, Xu, Xiaoyun, Li, Jie, Lin, Zhicheng, Xiong, Nian, Zhang, Zhentao, Xiong, Jing, Wang, Tao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5281633/
https://ncbi.nlm.nih.gov/pubmed/28197072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00013
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