Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

OBJECTIVE: Kinase Suppressor of Ras 2 (KSR2) is a molecular scaffold coordinating Raf/MEK/ERK signaling that is expressed at high levels in the brain. KSR2 disruption in humans and mice causes obesity and insulin resistance. Understanding the anatomical location and mechanism of KSR2 function should...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Metab
Main Authors: Guo, Lili, Costanzo-Garvey, Diane L., Smith, Deandra R., Neilsen, Beth K., MacDonald, Richard G., Lewis, Robert E.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279912/
https://ncbi.nlm.nih.gov/pubmed/28180061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.12.004
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