Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

Large-scale whole genome sequence datasets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole genome sequence data from the UK10K and the 1000 Genomes Projects into 35,981 study participants of European ancestry, followed...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Iotchkova, Valentina, Huang, Jie, Morris, John A., Jain, Deepti, Barbieri, Caterina, Walter, Klaudia, Min, Josine L., Chen, Lu, Astle, William, Cocca, Massimilian, Deelen, Patrick, Elding, Heather, Farmaki, Aliki-Eleni, Franklin, Christopher S., Franberg, Mattias, Gaunt, Tom R., Hofman, Albert, Jiang, Tao, Kleber, Marcus E., Lachance, Genevieve, Luan, Jian'an, Malerba, Giovanni, Matchan, Angela, Mead, Daniel, Memari, Yasin, Ntalla, Ioanna, Panoutsopoulou, Kalliope, Pazoki, Raha, Perry, John R.B., Rivadeneira, Fernando, Sabater-Lleal, Maria, Sennblad, Bengt, Shin, So-Youn, Southam, Lorraine, Traglia, Michela, van Dijk, Freerk, van Leeuwen, Elisabeth M., Zaza, Gianluigi, Zhang, Weihua, Amin, Najaf, Butterworth, Adam, Chambers, John C., Dedoussis, George, Dehghan, Abbas, Franco, Oscar H., Franke, Lude, Frontini, Mattia, Gambaro, Giovanni, Gasparini, Paolo, Hamsten, Anders, Issacs, Aaron, Kooner, Jaspal S., Kooperberg, Charles, Langenberg, Claudia, Marz, Winfried, Scott, Robert A., Swertz, Morris A., Toniolo, Daniela, Uitterlinden, Andre G., van Duijn, Cornelia M., Watkins, Hugh, Zeggini, Eleftheria, Maurano, Mathew T., Timpson, Nicholas J., Reiner, Alexander P., Auer, Paul L., Soranzo, Nicole
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279872/
https://ncbi.nlm.nih.gov/pubmed/27668658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3668
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