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Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes

Autophagy dysfunction is considered as a potential toxic mechanism of nanomaterials. Silica nanoparticles (SiNPs) can induce autophagy, but the specific mechanism involved remains unclear. Therefore, the aim of this study was to confirm the effects of SiNPs on autophagy dysfunction and explore the p...

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Bibliografski detalji
Izdano u:Int J Nanomedicine
Glavni autori: Wang, Ji, Yu, Yongbo, Lu, Ke, Yang, Man, Li, Yang, Zhou, Xianqing, Sun, Zhiwei
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279829/
https://ncbi.nlm.nih.gov/pubmed/28182147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S123596
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