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Steroid hormone receptors silence genes by a chromatin-targeted mechanism similar to those used for gene activation

How genes are repressed by steroid hormones remains a matter of debate, and several indirect mechanisms have been proposed. We found that the ligand-activated progesterone receptor recruits to the promoter of downregulated genes a repressor complex composed of HP1γ, the lysine demethylase LSD1, hist...

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Autors principals: Nacht, A. Silvina, Beato, Miguel, Vicent, Guillermo P.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279715/
https://ncbi.nlm.nih.gov/pubmed/27700223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2016.1242456
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