Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes

A close chromatin conformation precludes gene expression in eukaryotic cells. Genes activated by external cues have to overcome this repressive state by locally changing chromatin structure to a more open state. Although much is known about hormonal gene activation, how basal repression of regulated...

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Bibliografiske detaljer
Main Authors: Vicent, Guillermo Pablo, Nacht, A. Silvina, Zaurin, Roser, Font-Mateu, Jofre, Soronellas, Daniel, Le Dily, Francois, Reyes, Diana, Beato, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672650/
https://ncbi.nlm.nih.gov/pubmed/23699411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.215293.113
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