The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression()

Heparanase activity is highly implicated in cellular invasion and tumor metastasis, a consequence of cleavage of heparan sulfate and remodeling of the extracellular matrix underlying epithelial and endothelial cells. Heparanase expression is rare in normal epithelia, but is often induced in tumors,...

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Pubblicato in:Neoplasia
Autori principali: Singh, Preeti, Blatt, Alexandra, Feld, Sari, Zohar, Yaniv, Saadi, Esraa, Barki-Harrington, Liza, Hammond, Edward, Ilan, Neta, Vlodavsky, Israel, Chowers, Yehuda, Half, Elizabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2017
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279702/
https://ncbi.nlm.nih.gov/pubmed/28147305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.12.001
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