Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice

Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity. Results: Doxorubicin administration (20 mg/kg, in...

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Udgivet i:Antioxid Redox Signal
Main Authors: Vandenwijngaert, Sara, Swinnen, Melissa, Walravens, Ann-Sophie, Beerens, Manu, Gillijns, Hilde, Caluwé, Ellen, Tainsh, Robert E., Nathan, Daniel I., Allen, Kaitlin, Brouckaert, Peter, Bartunek, Jozef, Scherrer-Crosbie, Marielle, Bloch, Kenneth D., Bloch, Donald B., Janssens, Stefan P., Buys, Emmanuel S.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2017
Fag:
Forum Original Research CommunicationsNO Receptor – Part II of II (A. Beuve, Ed.)
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278809/
https://ncbi.nlm.nih.gov/pubmed/27505125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6542
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