Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648

Tigecycline (TGC) is a last-line drug for multidrug-resistant Enterobacteriaceae. We investigated the mechanism(s) underlying TGC nonsusceptibility (TGC resistant/intermediate) in Escherichia coli clinical isolates. The MIC of TGC was determined for 277 fluoroquinolone-susceptible isolates (ciproflo...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Sato, Toyotaka, Suzuki, Yuuki, Shiraishi, Tsukasa, Honda, Hiroyuki, Shinagawa, Masaaki, Yamamoto, Soh, Ogasawara, Noriko, Takahashi, Hiroki, Takahashi, Satoshi, Tamura, Yutaka, Yokota, Shin-ichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278711/
https://ncbi.nlm.nih.gov/pubmed/27855067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01654-16
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