A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

Somatic mutations activating MAPK and PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumours based on somatic expression of oncogenes that activate MAPK and PI3K signalling in neural progenitor cells and found that HRAS(...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Mayrhofer, Marie, Gourain, Victor, Reischl, Markus, Affaticati, Pierre, Jenett, Arnim, Joly, Jean-Stephane, Benelli, Matteo, Demichelis, Francesca, Poliani, Pietro Luigi, Sieger, Dirk, Mione, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278524/
https://ncbi.nlm.nih.gov/pubmed/27935819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.026500
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