Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival

The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504 resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in various cancers. We report that the FGF13 locus, comprising FGF13 and miR-504, is transcriptionally repressed by p53, defining an a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bublik, Débora R., Bursać, Slađana, Sheffer, Michal, Oršolić, Ines, Shalit, Tali, Tarcic, Ohad, Kotler, Eran, Mouhadeb, Odelia, Hoffman, Yonit, Fuchs, Gilad, Levin, Yishai, Volarević, Siniša, Oren, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278483/
https://ncbi.nlm.nih.gov/pubmed/27994142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614876114
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