Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critical step in p53 activation under these conditions. Here, we repo...

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書誌詳細
主要な著者: Bursać, Sladana, Brdovčak, Maja Cokarić, Pfannkuchen, Martin, Orsolić, Ines, Golomb, Lior, Zhu, Yan, Katz, Chen, Daftuar, Lilyn, Grabušić, Kristina, Vukelić, Iva, Filić, Vedrana, Oren, Moshe, Prives, Carol, Volarević, Siniša
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2012
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528581/
https://ncbi.nlm.nih.gov/pubmed/23169665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218535109
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