Laddar...
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
Somatic mutations within the antibody variable domains are critical to the immense capacity of the immune repertoire. Here, via a deep mutational scan, we dissect how mutations at all positions of the variable domains of a high-affinity anti-VEGF antibody G6.31 impact its antigen-binding function. T...
Sparad:
| I publikationen: | Proc Natl Acad Sci U S A |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2017
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278476/ https://ncbi.nlm.nih.gov/pubmed/28057863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613231114 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|