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Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism
Three-prime repair exonuclease 1 knockout (Trex1(−/−)) mice suffer from systemic inflammation caused largely by chronic activation of the cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase–interferon regulatory factor 3 (cGAS–STING–TBK1–IRF3) signaling pathway. We showed prev...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278463/ https://ncbi.nlm.nih.gov/pubmed/28069950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611113114 |
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