Utilising polymorphisms to achieve allele-specific genome editing in zebrafish

The advent of genome editing has significantly altered genetic research, including research using the zebrafish model. To better understand the selectivity of the commonly used CRISPR/Cas9 system, we investigated single base pair mismatches in target sites and examined how they affect genome editing...

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Bibliografische gegevens
Gepubliceerd in:Biol Open
Hoofdauteurs: Capon, Samuel J., Baillie, Gregory J., Bower, Neil I., da Silva, Jason A., Paterson, Scott, Hogan, Benjamin M., Simons, Cas, Smith, Kelly A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Ltd 2016
Onderwerpen:
Methods & Techniques
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278422/
https://ncbi.nlm.nih.gov/pubmed/27895053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.020974
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