Amphiregulin triggered epidermal growth factor receptor activation confers in vivo crizotinib‐resistance of EML4‐ALK lung cancer and circumvention by epidermal growth factor receptor inhibitors

Crizotinib, a first‐generation anaplastic lymphoma kinase (ALK) tyrosine‐kinase inhibitor, is known to be effective against echinoderm microtubule‐associated protein‐like 4 (EML4)‐ALK‐positive non‐small cell lung cancers. Nonetheless, the tumors subsequently become resistant to crizotinib and recur...

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Dades bibliogràfiques
Publicat a:Cancer Sci
Autors principals: Taniguchi, Hirokazu, Takeuchi, Shinji, Fukuda, Koji, Nakagawa, Takayuki, Arai, Sachiko, Nanjo, Shigeki, Yamada, Tadaaki, Yamaguchi, Hiroyuki, Mukae, Hiroshi, Yano, Seiji
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5276841/
https://ncbi.nlm.nih.gov/pubmed/27783866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13111
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