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The amphiregulin- epidermal growth factor receptor axis as a therapeutic target in sepsis

The Epidermal Growth Factor Receptor (EGFR) and its ligand, amphiregulin (AREG) are critical for epithelial cell proliferation but their important role in inflammation and infection is increasingly described. We recently discovered that the EGFR ligand, amphiregulin, could identify a cohort of infan...

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Principais autores: Rebecca Walsh, Timothy Arthur Chandos Snow, Alexandra Z. Martinez, David Brealey, Mervyn Singer, Abhishek Das, Nishkantha Arulkumaran, University College London Hospitals Critical Care Research Team
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-09-01
Serier:Frontiers in Immunology
Fag:
sepsis
intensive care unit
amphiregulin
epidermal growth factor receptor
monocyte
lymphocyte
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638244/full
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