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The amphiregulin- epidermal growth factor receptor axis as a therapeutic target in sepsis

The Epidermal Growth Factor Receptor (EGFR) and its ligand, amphiregulin (AREG) are critical for epithelial cell proliferation but their important role in inflammation and infection is increasingly described. We recently discovered that the EGFR ligand, amphiregulin, could identify a cohort of infan...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Rebecca Walsh, Timothy Arthur Chandos Snow, Alexandra Z. Martinez, David Brealey, Mervyn Singer, Abhishek Das, Nishkantha Arulkumaran, University College London Hospitals Critical Care Research Team
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-09-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
sepsis
intensive care unit
amphiregulin
epidermal growth factor receptor
monocyte
lymphocyte
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638244/full
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