Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to gain mechanistic insight into the pathophysiolo...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Ruby, Maxwell A., Massart, Julie, Hunerdosse, Devon M., Schönke, Milena, Correia, Jorge C., Louie, Sharon M., Ruas, Jorge L., Näslund, Erik, Nomura, Daniel K., Zierath, Juleen R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5276805/
https://ncbi.nlm.nih.gov/pubmed/28099843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.070
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