Combining multi-mutant and modular thermodynamic cycles to measure energetic coupling networks in enzyme catalysis

We measured and cross-validated the energetics of networks in Bacillus stearothermophilus Tryptophanyl-tRNA synthetase (TrpRS) using both multi-mutant and modular thermodynamic cycles. Multi-dimensional combinatorial mutagenesis showed that four side chains from this “molecular switch” move coordina...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Struct Dyn
Hauptverfasser: Carter, Charles W., Chandrasekaran, Srinivas Niranj, Weinreb, Violetta, Li, Li, Williams, Tishan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Crystallographic Association 2017
Schlagworte:
Transactions from the 66th Annual Meeting of the American Crystallographic Association (Aca)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272822/
https://ncbi.nlm.nih.gov/pubmed/28191480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4974218
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge