Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

Patients with leukemia who receive a T cell–depleted allogeneic stem cell graft followed by postponed donor lymphocyte infusion (DLI) can experience graft-versus-leukemia (GVL) reactivity, with a lower risk of graft-versus-host disease (GVHD). Here, we have investigated the magnitude, diversity, and...

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Vydáno v:J Clin Invest
Hlavní autoři: van Bergen, Cornelis A.M., van Luxemburg-Heijs, Simone A.P., de Wreede, Liesbeth C., Eefting, Matthijs, von dem Borne, Peter A., van Balen, Peter, Heemskerk, Mirjam H.M., Mulder, Arend, Claas, Fransiscus H.J., Navarrete, Marcelo A., Honders, Wilhelmina M., Rutten, Caroline E., Veelken, Hendrik, Jedema, Inge, Halkes, Constantijn J.M., Griffioen, Marieke, Falkenburg, J.H. Frederik
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272193/
https://ncbi.nlm.nih.gov/pubmed/28067665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86175
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