Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells

Expansion of mesenchymal stromal/stem cells (MSCs) used in clinical practices may be associated with accumulation of genetic instability. Understanding temporal and mechanistic aspects of this process is important for improving stem cell therapy protocols. We used γH2AX foci as a marker of a genetic...

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Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Pustovalova, Margarita, Grekhova, Anna, Astrelina, Tatiana, Nikitina, Viktoria, Dobrovolskaya, Ekaterina, Suchkova, Yulia, Kobzeva, Irina, Usupzhanova, Darya, Vorobyeva, Natalia, Samoylov, Aleksandr, Bushmanov, Andrey, Ozerov, Ivan V., Zhavoronkov, Alex, Leonov, Sergey, Klokov, Dmitry, Osipov, Andreyan N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270682/
https://ncbi.nlm.nih.gov/pubmed/27959319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101142
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