Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution

The interaction of glutamate and dopamine in the striatum is heavily dependent on signaling pathways that converge on the regulatory protein DARPP-32. The efficacy of dopamine/D1 receptor/PKA signaling is regulated by DARPP-32 phosphorylated at Thr-34 (the PKA site), a process that inhibits protein...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Nishi, Akinori, Matamales, Miriam, Musante, Veronica, Valjent, Emmanuel, Kuroiwa, Mahomi, Kitahara, Yosuke, Rebholz, Heike, Greengard, Paul, Girault, Jean-Antoine, Nairn, Angus C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270488/
https://ncbi.nlm.nih.gov/pubmed/27998980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752402
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