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Cell-type specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

DARPP-32 is a dual function protein kinase/phosphatase inhibitor which plays a vital role in striatal signaling. The phosphorylation of DARPP-32 at T34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs; however these drugs are known to have opposing behavioral an...

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Bibliografski detalji
Glavni autori: Bateup, Helen S., Svenningsson, Per, Kuroiwa, Mahomi, Gong, Shiaoching, Nishi, Akinori, Heintz, Nathaniel, Greengard, Paul
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737705/
https://ncbi.nlm.nih.gov/pubmed/18622401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2153
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