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Metnase Mediates Loading of Exonuclease 1 onto Single Strand Overhang DNA for End Resection at Stalled Replication Forks

Stalling at DNA replication forks generates stretches of single-stranded (ss) DNA on both strands that are exposed to nucleolytic degradation, potentially compromising genome stability. One enzyme crucial for DNA replication fork repair and restart of stalled forks in human is Metnase (also known as...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Kim, Hyun-Suk, Williamson, Elizabeth A., Nickoloff, Jac A., Hromas, Robert A., Lee, Suk-Hee
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270484/
https://ncbi.nlm.nih.gov/pubmed/27974460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745646
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