Trimming of damaged 3′ overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases

Both Metnase and Artemis possess endonuclease activities that trim 3′ overhangs of duplex DNA. To assess the potential of these enzymes for facilitating resolution of damaged ends during double-strand break rejoining, substrates bearing a variety of normal and structurally modified 3′ overhangs were...

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Main Authors: Mohapatra, Susovan, Yannone, Steven M., Lee, Suk-Hee, Hromas, Robert A., Akopiants, Konstantin, Menon, Vijay, Ramsden, Dale A., Povirk, Lawrence F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660496/
https://ncbi.nlm.nih.gov/pubmed/23602515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.03.005
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