Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities

Extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (DAT) and serotonin (SERT) transporters, respectively. Numerous studies have investigated the DAT and SERT structural elements contributing to inhibitor and substrate binding. To date, crystallographic stu...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Sweeney, Carolyn G., Tremblay, Bradford P., Stockner, Thomas, Sitte, Harald H., Melikian, Haley E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270474/
https://ncbi.nlm.nih.gov/pubmed/27986813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762872
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items