Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities

Extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (DAT) and serotonin (SERT) transporters, respectively. Numerous studies have investigated the DAT and SERT structural elements contributing to inhibitor and substrate binding. To date, crystallographic stu...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Sweeney, Carolyn G., Tremblay, Bradford P., Stockner, Thomas, Sitte, Harald H., Melikian, Haley E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Neurobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270474/
https://ncbi.nlm.nih.gov/pubmed/27986813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762872
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