Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

The high-resolution crystal structure of the leucine transporter (LeuT) is frequently used as a template for homology models of the dopamine transporter (DAT). Although similar in structure, DAT differs considerably from LeuT in a number of ways: (i) when compared to LeuT, DAT has very long intracel...

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Main Authors: Stockner, Thomas, Montgomery, Therese R., Kudlacek, Oliver, Weissensteiner, Rene, Ecker, Gerhard F., Freissmuth, Michael, Sitte, Harald H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578762/
https://ncbi.nlm.nih.gov/pubmed/23436987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002909
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