Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities

Extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (DAT) and serotonin (SERT) transporters, respectively. Numerous studies have investigated the DAT and SERT structural elements contributing to inhibitor and substrate binding. To date, crystallographic stu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Sweeney, Carolyn G., Tremblay, Bradford P., Stockner, Thomas, Sitte, Harald H., Melikian, Haley E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Neurobiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270474/
https://ncbi.nlm.nih.gov/pubmed/27986813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762872
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