Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities

Extracellular dopamine and serotonin concentrations are determined by the presynaptic dopamine (DAT) and serotonin (SERT) transporters, respectively. Numerous studies have investigated the DAT and SERT structural elements contributing to inhibitor and substrate binding. To date, crystallographic stu...

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Vydáno v:J Biol Chem
Hlavní autoři: Sweeney, Carolyn G., Tremblay, Bradford P., Stockner, Thomas, Sitte, Harald H., Melikian, Haley E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270474/
https://ncbi.nlm.nih.gov/pubmed/27986813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762872
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