Study of LRRK2 variation in tauopathy: progressive supranuclear palsy and corticobasal degeneration

BACKGROUND: Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common genetic cause of Parkinson’s disease (PD). Unexpectedly, tau pathology has been reported in a subset of LRRK2 mutation carriers. METHODS: To estimate the frequency of pathogenic LRRK2 mutations, and to evaluat...

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Vydáno v:Mov Disord
Hlavní autoři: Sanchez-Contreras, Monica, Heckman, Michael G., Tacik, Pawel, Diehl, Nancy, Brown, Patricia H., Soto-Ortolaza, Alexandra I., Christopher, Elizabeth A., Walton, Ronald L., Ross, Owen A., Golbe, Lawrence I., Graff-Radford, Neill, Wszolek, Zbigniew K., Dickson, Dennis W., Rademakers, Rosa
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269612/
https://ncbi.nlm.nih.gov/pubmed/27709685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.26815
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