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Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures

Mitochondrial health is important in ageing and dysfunctional oxidative phosphorylation (OXPHOS) accelerates ageing and influences neurodegeneration. Mitochondrial DNA (mtDNA) codes for vital OXPHOS subunits and mtDNA background has been associated with neurodegeneration; however, no study has chara...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Valentino, Rebecca R., Tamvaka, Nikoleta, Heckman, Michael G., Johnson, Patrick W., Soto-Beasley, Alexandra I., Walton, Ronald L., Koga, Shunsuke, Uitti, Ryan J., Wszolek, Zbigniew K., Dickson, Dennis W., Ross, Owen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495714/
https://ncbi.nlm.nih.gov/pubmed/32943110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01035-z
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