Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

Hyperglycemia (HG) stimulates the production of reactive oxygen species in the heart through activation of NADPH oxidase 2 (NOX2). This production is independent of glucose metabolism but requires sodium/glucose cotransporters (SGLT). Seven SGLT isoforms (SGLT1 to 6 and sodium-myoinositol cotranspor...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Van Steenbergen, Anne, Balteau, Magali, Ginion, Audrey, Ferté, Laura, Battault, Sylvain, Ravenstein, Christophe de Meester de, Balligand, Jean-Luc, Daskalopoulos, Evangelos-Panagiotis, Gilon, Patrick, Despa, Florin, Despa, Sanda, Vanoverschelde, Jean-Louis, Horman, Sandrine, Koepsell, Hermann, Berry, Gerard, Hue, Louis, Bertrand, Luc, Beauloye, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269587/
https://ncbi.nlm.nih.gov/pubmed/28128227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41166
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