AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism

We have previously demonstrated that systemic AMP-activated protein kinase α1 (AMPKα1) invalidation enhanced adverse LV remodelling by increasing fibroblast proliferation, while myodifferentiation and scar maturation were impaired. We thus hypothesised that fibroblastic AMPKα1 was a key signalling e...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Dufeys, Cécile, Daskalopoulos, Evangelos-Panagiotis, Castanares-Zapatero, Diego, Conway, Simon J., Ginion, Audrey, Bouzin, Caroline, Ambroise, Jérôme, Bearzatto, Bertrand, Gala, Jean-Luc, Heymans, Stephane, Papageorgiou, Anna-Pia, Vinckier, Stefan, Cumps, Julien, Balligand, Jean-Luc, Vanhaverbeke, Maarten, Sinnaeve, Peter, Janssens, Stefan, Bertrand, Luc, Beauloye, Christophe, Horman, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
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Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873123/
https://ncbi.nlm.nih.gov/pubmed/33564961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00846-y
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