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Impact of the spotted microarray preprocessing method on fold-change compression and variance stability
BACKGROUND: The standard approach for preprocessing spotted microarray data is to subtract the local background intensity from the spot foreground intensity, to perform a log2 transformation and to normalize the data with a global median or a lowess normalization. Although well motivated, standard a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3224096/ https://ncbi.nlm.nih.gov/pubmed/22026942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-413 |
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