AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ribosomal S6 protein kinase, calcineurin/nuclear fac...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gélinas, Roselle, Mailleux, Florence, Dontaine, Justine, Bultot, Laurent, Demeulder, Bénédicte, Ginion, Audrey, Daskalopoulos, Evangelos P., Esfahani, Hrag, Dubois-Deruy, Emilie, Lauzier, Benjamin, Gauthier, Chantal, Olson, Aaron K., Bouchard, Bertrand, Des Rosiers, Christine, Viollet, Benoit, Sakamoto, Kei, Balligand, Jean-Luc, Vanoverschelde, Jean-Louis, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785516/
https://ncbi.nlm.nih.gov/pubmed/29371602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02795-4
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