AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ribosomal S6 protein kinase, calcineurin/nuclear fac...

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Опубликовано в: :Nat Commun
Главные авторы: Gélinas, Roselle, Mailleux, Florence, Dontaine, Justine, Bultot, Laurent, Demeulder, Bénédicte, Ginion, Audrey, Daskalopoulos, Evangelos P., Esfahani, Hrag, Dubois-Deruy, Emilie, Lauzier, Benjamin, Gauthier, Chantal, Olson, Aaron K., Bouchard, Bertrand, Des Rosiers, Christine, Viollet, Benoit, Sakamoto, Kei, Balligand, Jean-Luc, Vanoverschelde, Jean-Louis, Beauloye, Christophe, Horman, Sandrine, Bertrand, Luc
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785516/
https://ncbi.nlm.nih.gov/pubmed/29371602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02795-4
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