Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1

Casein kinase 1 delta (CK1δ) is a conserved serine/threonine protein kinase that regulates diverse cellular processes. Mice lacking CK1δ have a perinatal lethal phenotype and typically weigh 30% less than their wild type littermates. However, the causes of death and small size are unknown. We observ...

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Bibliographic Details
Published in:PLoS One
Main Authors: Greer, Yoshimi Endo, Gao, Bo, Yang, Yingzi, Nussenzweig, Andre, Rubin, Jeffrey S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268481/
https://ncbi.nlm.nih.gov/pubmed/28125685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170903
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