Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm

Cardiac rhythm is extremely robust, generating 2 billion contraction cycles during the average human life span. Transcriptional control of cardiac rhythm is poorly understood. We found that removal of the transcription factor gene Tbx5 from the adult mouse caused primary spontaneous and sustained at...

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Pubblicato in:Sci Transl Med
Autori principali: Nadadur, Rangarajan D., Broman, Michael T., Boukens, Bastiaan, Mazurek, Stefan R., Yang, Xinan, van den Boogaard, Malou, Bekeny, Jenna, Gadek, Margaret, Ward, Tarsha, Zhang, Min, Qiao, Yun, Martin, James F., Seidman, Christine E., Seidman, Jon, Christoffels, Vincent, Efimov, Igor R., McNally, Elizabeth M., Weber, Christopher R., Moskowitz, Ivan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266594/
https://ncbi.nlm.nih.gov/pubmed/27582060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf4891
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