Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm

Cardiac rhythm is extremely robust, generating 2 billion contraction cycles during the average human life span. Transcriptional control of cardiac rhythm is poorly understood. We found that removal of the transcription factor gene Tbx5 from the adult mouse caused primary spontaneous and sustained at...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Transl Med
Egile Nagusiak: Nadadur, Rangarajan D., Broman, Michael T., Boukens, Bastiaan, Mazurek, Stefan R., Yang, Xinan, van den Boogaard, Malou, Bekeny, Jenna, Gadek, Margaret, Ward, Tarsha, Zhang, Min, Qiao, Yun, Martin, James F., Seidman, Christine E., Seidman, Jon, Christoffels, Vincent, Efimov, Igor R., McNally, Elizabeth M., Weber, Christopher R., Moskowitz, Ivan P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266594/
https://ncbi.nlm.nih.gov/pubmed/27582060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf4891
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