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Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma

Small molecule-drug conjugates (SMDCs) are increasingly being considered as an alternative to antibody-drug conjugates (ADCs) for the selective delivery of anticancer agents to the tumor site, sparing normal tissues. Carbonic anhydrase IX (CAIX) is a membrane-bound enzyme, which is over-expressed in...

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Bibliografske podrobnosti
izdano v:J Control Release
Main Authors: Cazzamalli, Samuele, Corso, Alberto Dal, Neri, Dario
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266555/
https://ncbi.nlm.nih.gov/pubmed/27890855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.11.023
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