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Chemically-defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: a comparative analysis

We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically-defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Cazzamalli, Samuele, Dal Corso, Alberto, Widmayer, Fontaine, Neri, Dario
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844464/
https://ncbi.nlm.nih.gov/pubmed/29342352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13361
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