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Chemically-defined antibody- and small molecule-drug conjugates for in vivo tumor targeting applications: a comparative analysis
We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically-defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.
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| Gepubliceerd in: | J Am Chem Soc |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5844464/ https://ncbi.nlm.nih.gov/pubmed/29342352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13361 |
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