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Stiffened Extracellular Matrix and Signaling from Stromal Fibroblasts via Osteoprotegerin Regulate Tumor Cell Invasion in a 3-D Tumor in Situ Model

Several changes have been described in the stroma surrounding a tumor, including changes in cellular composition, altered extracellular matrix composition and organization, and increases in stiffness. Tumor cells are influenced by the composition, organization, and mechanical properties of the micro...

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Detalhes bibliográficos
Publicado no:Cancer Microenviron
Main Authors: McLane, Joshua S., Ligon, Lee A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264661/
https://ncbi.nlm.nih.gov/pubmed/27654881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12307-016-0188-z
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