Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial ischemia/reperfusion (MI/R) injury. Melatonin has been reported to be a safe and potent cardioprotective agent. However, its role on mitocho...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Yu, Liming, Gong, Bing, Duan, Weixun, Fan, Chongxi, Zhang, Jian, Li, Zhi, Xue, Xiaodong, Xu, Yinli, Meng, Dandan, Li, Buying, Zhang, Meng, Bin Zhang, Jin, Zhenxiao, Yu, Shiqiang, Yang, Yang, Wang, Huishan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264601/
https://ncbi.nlm.nih.gov/pubmed/28120943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41337
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